170. High intensity focused ultrasound (HIFU) ablation in the treatment of breast cancers: A systematic review

Results: A total of 298 patients were identified, of which 270 patients were diagnosed with Invasive ductal Carcinoma (IDC), and 28 with invasive lobular carcinoma (ILC). The Chi-squared test was used to analyse data, and a strong statistically significant relationship was found between LVI and sentinel node positivity (p<0.001) for all patients observed in this study. There was also a statistically significant association between LVI in core biopsy tissue and IDC overall, and was particularly so for Grade 2 and 3 (p<0.001). This strong association remains so even after adjusting for tumour size. Conclusions: Our study suggests that a subgroup of breast cancer patients with Grade 2 and 3 IDC, could be offered Axillary lymph node clearance on the basis of LVI in their pre-operative core biopsy. Further large scale prospective studies are required to substantiate our findings and also to fully assess the link for ILC of all grades with LVI. No conflict of interest.